Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10714781 | 0.79 | METAP2 (0.35) | BRD4CREBBPMAOBKDM4EALDH1A1 | |
| SCHEMBL10714792 | 0.77 | ALDH1A1 (0.36) | BRD4TNKS2KDM4EALDH1A1PPARG | |
| SCHEMBL10713237 | 0.77 | MAOA (0.43) | BRD4BRPF1CREBBPMAOAMAOB | |
| SCHEMBL10711443 | 0.74 | PGR (0.49) | BRD4BRPF1CREBBPMAOAMAOB | |
| SCHEMBL10711747 | 0.74 | CREBBP (0.43) | BRD4BRPF1CREBBPGAAKDM4E | |
| SCHEMBL10712785 | 0.71 | KDM4E (0.33) | BRD4CREBBPKDM4EALDH1A1PTGS2 | |
| SCHEMBL10713397 | 0.71 | BRD4 (0.33) | BRD4CREBBPMAOAMAOBKDM4E | |
| SCHEMBL10921424 | 0.70 | CCNB2 (0.39) | BRD4BRPF1CREBBPTNKS2POLB | |
| SCHEMBL10710511 | 0.68 | GRIA1 (0.38) | BRPF1CREBBPTNKS2ALDH1A1POLB | |
| SCHEMBL10714017 | 0.67 | GRIA1 (0.49) | BRD4TNKS2POLBPPARGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670566-A | ANTIIFLAMMATORY AGENTS, ANTICOAGULANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-06-02 | — | — | US | disclosed |
| US-4440785-A | Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation | A. H. ROBINS COMPANY, INC. (US) | 1984-04-03 | — | — | US | disclosed |
| EP-0089426-A1 | 2-Amino-6-biphenylacetic acids | A.H. ROBINS COMPANY, INCORPORATED (US) | 1983-09-28 | — | — | EP | disclosed |
| US-4333951-A | MUSCLE RELAXANTS, ANTIINFLAMMATORY AGENTS | A. H. ROBINS COMPANY, INC. (US) | 1982-06-08 | — | — | US | disclosed |