Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 3/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6242825 | 0.89 | CASP1 (0.45) | CASP1ALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL243227 | 0.89 | CASP1 (0.45) | CASP1ALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL1140146 | 0.80 | MMP2 (0.46) | CASP1PTPN1ALDH1A1MAPTTAAR1 | |
| SCHEMBL4211263 | 0.80 | MMP2 (0.46) | MMP8MMP14CA14NPC1RAB9A | |
| SCHEMBL29139680 | 0.80 | NPC1 (0.41) | MMP8MMP14CA14ALDH1A1MAPT | |
| SCHEMBL4350738 | 0.76 | RAB9A (0.49) | ALDH1A1KDM4EMAPTNPC1HTT | |
| SCHEMBL1312515 | 0.74 | ADAMTS4 (0.56) | MMP8MMP14CA14PTPN1PTPN11 | |
| SCHEMBL6242797 | 0.74 | ADAMTS4 (0.56) | MMP8MMP14CA14PTPN1PTPN11 | |
| SCHEMBL515505 | 0.74 | ADAMTS4 (0.56) | MMP8MMP14CA14PTPN1PTPN11 | |
| SCHEMBL27700710 | 0.74 | HSD17B10 (0.45) | ALDH1A1KDM4EMAPTTAAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4654356-A | BRONCHODILATORS, ANTIASTHMA, THROMBOSIS ANTICOAGULANTS | E. R. SQUIBB & SONS, INC. (US) | 1987-03-31 | — | — | US | disclosed |
| EP-0210664-A2 | 7-oxabicycloheptane substituted diacid diamide prostaglandin analogs | E.R. Squibb & Sons, Inc. (US) | 1987-02-04 | — | — | EP | disclosed |