Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 12/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 4/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10727110 | 0.91 | MAPT (0.39) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL10730685 | 0.85 | SMN1; SMN2 (0.38) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL10730511 | 0.77 | LMNA (0.36) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL13464716 | 0.72 | SMN1; SMN2 (0.50) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL10650242 | 0.71 | SMN1; SMN2 (0.41) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL10648684 | 0.70 | SMN1; SMN2 (0.43) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL10650433 | 0.70 | HRH3 (0.46) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL10646023 | 0.69 | SMN1; SMN2 (0.40) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL8924482 | 0.69 | SMN1; SMN2 (0.50) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL10648034 | 0.68 | HRH3 (0.50) | PDE3BPDE3ASMN1; SMN2PDE2APDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112987-B1 | IMIDAZOLYLALKYLTHIENYL-TETRAHYDROPYRIDAZINES AND PROCESS FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1987-04-01 | — | — | EP | disclosed |
| US-4643998-A | Imidazolylalkylthienyl tetrahydropyridazines and processes for their use | A. NATTERMAN & CIE GMBH (DE) | 1987-02-17 | — | — | US | disclosed |
| EP-0112987-A1 | Imidazolylalkylthienyl-tetrahydropyridazines and process for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-07-11 | — | — | EP | disclosed |