Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.56 |
| ▸ | CTSB | P07858 | 3/20 | 0.56 |
| ▸ | REN | P00797 | 5/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.43 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10724160 | 0.93 | CTSB (0.49) | CTSKCTSBRENCASP3MME | |
| SCHEMBL10720236 | 0.92 | CTSB (0.49) | CTSKCTSBRENCASP3MME | |
| SCHEMBL10725450 | 0.91 | REN (0.50) | CTSKCTSBRENCASP3MME | |
| SCHEMBL10722068 | 0.91 | CTSB (0.48) | CTSKCTSBRENCASP3MME | |
| SCHEMBL10720888 | 0.85 | REN (0.61) | CTSKCTSBRENCTSD | |
| SCHEMBL10720900 | 0.85 | REN (0.61) | CTSKCTSBRENCTSD | |
| SCHEMBL10724666 | 0.84 | CTSK (0.56) | CTSKCTSBRENCASP3CTSD | |
| SCHEMBL10724673 | 0.84 | CTSK (0.56) | CTSKCTSBRENCASP3CTSD | |
| SCHEMBL10725334 | 0.83 | REN (0.62) | CTSKCTSBRENCASP3CTSD | |
| SCHEMBL10725341 | 0.83 | REN (0.62) | CTSKCTSBRENCASP3CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4698329-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1987-10-06 | — | — | US | disclosed |
| EP-0152255-A2 | New renin-inhibitory peptides and their use | SANKYO COMPANY LIMITED (JP) | 1985-08-21 | — | — | EP | disclosed |