SCHEMBL10722068

CCC(C)[C@@H](CO)NC(=O)CP(=O)(O)C(CC(C)C)NC(=O)[C@H](Cc1cscn1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)OCc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 18)

	gene	UniProt	supporting neighbours	confidence
▸	CTSB	P07858	1/20	0.48

▸	CTSK	P43235	1/20	0.48

▸	REN	P00797	10/20	0.47

▸	CASP3	P42574	1/20	0.41

▸	MME	P08473	2/20	0.39

▸	ECE1	P42892	1/20	0.39

▸	ACE2	Q9BYF1	2/20	0.39

▸	CTSD	P07339	1/20	0.38

▸	ANPEP	P15144	1/20	0.38

▸	ERAP1	Q9NZ08	1/20	0.38

▸	MMP2	P08253	1/20	0.38

▸	MMP7	P09237	1/20	0.38

▸	MMP9	P14780	1/20	0.38

▸	MMP8	P22894	1/20	0.38

▸	MMP14	P50281	1/20	0.38

▸	ACE	P12821	1/20	0.37

▸	CPA1	P15085	1/20	0.37

▸	PSMB5	P28074	2/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10720236	0.91	CTSB (0.49)	CTSBCTSKRENCASP3MME
SCHEMBL10725349	0.91	CTSK (0.56)	CTSBCTSKRENCASP3MME
SCHEMBL10725450	0.90	REN (0.50)	CTSBCTSKRENCASP3MME
SCHEMBL10720656	0.87	REN (0.56)	CTSBCTSKRENCTSD
SCHEMBL10720663	0.87	REN (0.56)	CTSBCTSKRENCTSD
SCHEMBL10724160	0.87	CTSB (0.49)	CTSBCTSKRENCASP3MME
SCHEMBL11018235	0.84	REN (0.47)	CTSBCTSKRENCASP3MME
SCHEMBL11018251	0.84	REN (0.47)	CTSBCTSKRENCASP3MME
SCHEMBL10722073	0.83	CTSB (0.47)	CTSBCTSKRENCASP3MME
SCHEMBL10720537	0.82	REN (0.50)	CTSBCTSKREN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-4698329-A	HYPOTENSIVE AGENTS	SANKYO COMPANY, LIMITED (JP)	1987-10-06	—	—	US	disclosed