Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667516 | 0.89 | MAPT (0.41) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL9666432 | 0.87 | DRD2 (0.42) | ALDH1A1KMT2AMEN1LMNAPOLB | |
| SCHEMBL9667449 | 0.86 | MEN1 (0.46) | ALDH1A1RAB9AHPGDKMT2AMEN1 | |
| SCHEMBL10745385 | 0.84 | PARK7 (0.40) | ALDH1A1HPGDKMT2ALMNAPOLB | |
| SCHEMBL9666026 | 0.82 | SMN1; SMN2 (0.43) | ALDH1A1RAB9AKMT2AMEN1LMNA | |
| SCHEMBL10738159 | 0.82 | MAPT (0.44) | ALDH1A1RAB9AKMT2AMEN1POLB | |
| SCHEMBL7242408 | 0.81 | ALDH1A1 (0.43) | ALDH1A1RAB9AHPGDKMT2AMEN1 | |
| SCHEMBL9668245 | 0.81 | USP2 (0.42) | ALDH1A1KMT2AMEN1LMNAGAA | |
| SCHEMBL9667464 | 0.80 | RECQL (0.39) | ALDH1A1RAB9AKMT2AMEN1LMNA | |
| SCHEMBL7096272 | 0.79 | KMT2A (0.54) | ALDH1A1RAB9AKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4686224-A | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1987-08-11 | — | — | US | disclosed |
| US-4644005-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1987-02-17 | — | — | US | disclosed |
| EP-0181136-A2 | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1986-05-14 | — | — | EP | disclosed |