Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10732555 | 0.82 | GRIN2B (0.48) | SMN1; SMN2POLBMEN1KMT2ARAB9A | |
| SCHEMBL10733734 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2POLBMEN1KMT2ARAB9A | |
| SCHEMBL10733533 | 0.82 | POLB (0.55) | SMN1; SMN2POLBMEN1KMT2ARAB9A | |
| SCHEMBL10801047 | 0.81 | TRPA1 (0.38) | SMN1; SMN2POLBGRIN2B | |
| SCHEMBL31055021 | 0.74 | SRC (0.45) | SMN1; SMN2POLBMEN1KMT2ARAB9A | |
| SCHEMBL10738872 | 0.72 | HSD17B10 (0.47) | SMN1; SMN2POLBMEN1KMT2ARAB9A | |
| SCHEMBL10739317 | 0.72 | KMT2A (0.49) | POLBMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL10738569 | 0.72 | KMT2A (0.51) | SMN1; SMN2POLBMEN1KMT2ARAB9A | |
| SCHEMBL10740587 | 0.69 | RAB9A (0.48) | SMN1; SMN2POLBKMT2ARAB9ANPC1 | |
| SCHEMBL10733675 | 0.69 | PKM (0.49) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4636509-A | Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor | GLAXO GROUP LIMITED (GB) | 1987-01-13 | — | — | US | disclosed |