Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | HTR3A | P46098 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.41 |
| ▸ | HTR3B | O95264 | 2/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27896130 | 0.81 | HRH3 (0.45) | CYP1A2HRH3ALDH1A1KDM4EMAPT | |
| SCHEMBL10746496 | 0.78 | CYP2C19 (0.46) | CYP1A2ALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL24319168 | 0.74 | HRH4 (0.65) | HRH4CYP1A2HRH3HTR3AALDH1A1 | |
| SCHEMBL12615095 | 0.70 | HRH4 (0.47) | HRH4CYP1A2HRH3HTR3AALDH1A1 | |
| SCHEMBL1569984 | 0.70 | HRH4 (0.45) | HRH4CYP1A2HRH3HTR3AALDH1A1 | |
| SCHEMBL1775874 | 0.69 | HRH4 (0.64) | HRH4CYP1A2HRH3HTR3AALDH1A1 | |
| SCHEMBL27892281 | 0.69 | HTR3A (0.46) | HRH4CYP1A2HRH3HTR3AALDH1A1 | |
| SCHEMBL12497703 | 0.68 | HRH4 (0.57) | HRH4CYP1A2HRH3HTR3AALDH1A1 | |
| SCHEMBL8925000 | 0.68 | HRH4 (0.46) | HRH4HTR3AALDH1A1KDM4EGLA | |
| SCHEMBL9558132 | 0.68 | SORD (0.55) | HRH4CYP1A2HRH3HTR3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541785-B | Substituted dihydropyrazolones and use thereof as HIF-prolyl-4 -hydroxylase inhibitors | BAYER IP GMBH | 2014-03-12 | — | — | CN | disclosed |
| CN-101541785-A | Substituted dihydropyrazolones and use thereof as HIF-prolyl-4 -hydroxylase inhibitors | BAYER SCHERING PHARMA AG (DE) | 2009-09-23 | — | — | CN | disclosed |
| US-4435401-A | 4-Amino-6,7-dimethoxy-2-(4-heteroaryl-piperazino)quinazoline antihypertensives | PFIZER INC. (US) | 1984-03-06 | — | — | US | disclosed |