Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 6/20 | 0.67 |
| ▸ | MAOB | P27338 | 11/20 | 0.62 |
| ▸ | MAOA | P21397 | 10/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1027756 | 0.81 | TGM2 (1.00) | TGM2MAOBMAOAALDH1A1CES1 | |
| 5-Methoxyisatin SCHEMBL28560213 | 0.72 | ALDH1A1 (0.84) | TGM2MAOBMAOAALDH1A1CES1 | |
| 5-Methoxyisatin SCHEMBL29506298 | 0.72 | ALDH1A1 (1.00) | TGM2MAOBMAOAALDH1A1CES1 | |
| 5-Methoxyisatin SCHEMBL21602 | 0.72 | ALDH1A1 (1.00) | TGM2MAOBMAOAALDH1A1CES1 | |
| SCHEMBL281586 | 0.72 | CES1 (0.55) | TGM2MAOBMAOAALDH1A1CES1 | |
| SCHEMBL30397534 | 0.72 | CES1 (0.55) | TGM2MAOBMAOAALDH1A1CES1 | |
| 5-Methoxyisatin SCHEMBL3935863 | 0.70 | ALDH1A1 (0.96) | TGM2MAOBMAOAALDH1A1CES1 | |
| SCHEMBL28812042 | 0.69 | MAOA (0.59) | MAOBMAOA | |
| SCHEMBL23385135 | 0.69 | TGM2 (0.71) | TGM2MAOBMAOAALDH1A1CES1 | |
| Isatin SCHEMBL28259465 | 0.69 | CES1 (0.86) | TGM2MAOBMAOAALDH1A1CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274280-A2 | BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS | Biolipox AB (SE) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009127822-A2 | BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS | BIOLIPOX AB (SE) | 2009-10-22 | — | — | WO | disclosed |