SCHEMBL1027756

SCHEMBL1027756

O=C1Nc2ccc(Oc3ccc4c(c3)C(=O)C(=O)N4)cc2C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TGM2 P21980 6/20 1.00
MAOB P27338 10/20 0.83
MAOA P21397 9/20 0.83
ALDH1A1 P00352 1/20 0.73
CES1 P23141 4/20 0.67
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA9 Q16790 1/20 0.53
CAPN9 O14815 1/20 0.51
CASP3 P42574 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
5-Methoxyisatin SCHEMBL21602 0.85 ALDH1A1 (1.00) TGM2MAOBMAOAALDH1A1CES1
5-Methoxyisatin SCHEMBL29506298 0.85 ALDH1A1 (1.00) TGM2MAOBMAOAALDH1A1CES1
SCHEMBL23385135 0.84 TGM2 (0.71) TGM2MAOBMAOAALDH1A1CES1
SCHEMBL5697136 0.84 TGM2 (1.00) TGM2MAOBMAOAALDH1A1CES1
5-Methoxyisatin SCHEMBL3935863 0.83 ALDH1A1 (0.96) TGM2MAOBMAOAALDH1A1CES1
SCHEMBL1075112 0.81 TGM2 (0.67) TGM2MAOBMAOAALDH1A1CES1
SCHEMBL2372943 0.80 ALDH1A1 (0.68) TGM2MAOBMAOAALDH1A1CES1
SCHEMBL457929 0.80 CES1 (1.00) TGM2MAOBMAOAALDH1A1CES1
SCHEMBL4627666 0.80 TGM2 (0.67) TGM2MAOBMAOAALDH1A1CES1
SCHEMBL29475283 0.80 CES1 (1.00) TGM2MAOBMAOAALDH1A1CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1362579-B1 Agent for dyeing keratinous fibres HENKEL KGAA (DE) 2006-05-24 EP claimed
EP-1362579-A1 Agent for dyeing keratinous fibres Henkel Kommanditgesellschaft auf Aktien (DE) 2003-11-19 EP claimed
US-20250101200-A1 POLYMERIC MATERIALS WITH REDUCED ALDEHYDE CONTENT AND PROCESS CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2025-03-27 US disclosed
EP-4473037-A1 POLYMERIC MATERIALS WITH REDUCED ALDEHYDE CONTENT AND PROCESS Colormatrix Holdings, Inc. (US) 2024-12-11 EP disclosed
CN-118591578-A Polymeric materials and methods with reduced aldehyde content 彩色矩阵控股公司 2024-09-03 CN disclosed
WO-2023144607-A1 POLYMERIC MATERIALS WITH REDUCED ALDEHYDE CONTENT AND PROCESS COLORMATRIX HOLDINGS, INC. (US) 2023-08-03 WO disclosed
WO-2023144607-A1 POLYMERIC MATERIALS WITH REDUCED ALDEHYDE CONTENT AND PROCESS COLORMATRIX HOLDINGS, INC. (US) 2023-08-03 WO disclosed
US-20110071197-A1 BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS BIOLIPOX AB (LV) 2011-03-24 US disclosed
EP-2274280-A2 BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS Biolipox AB (SE) 2011-01-19 EP disclosed
WO-2009127822-A2 BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS BIOLIPOX AB (SE) 2009-10-22 WO disclosed
US-20090220554-A1 Transglutaminase Inhibitors and Methods of Use Thereof PHARMIX CORPORATION 2009-09-03 US disclosed
US-20090220554-A1 Transglutaminase Inhibitors and Methods of Use Thereof PHARMIX CORPORATION 2009-09-03 US disclosed
US-20090220554-A1 Transglutaminase Inhibitors and Methods of Use Thereof PHARMIX CORPORATION 2009-09-03 US disclosed
EP-1954285-A2 TRANSGLUTAMINASE INHIBITORS AND METHODS OF USE THEREOF Alvine Pharmaceuticals, Inc. (US) 2008-08-13 EP disclosed
WO-2007050795-A2 TRANSGLUTAMINASE INHIBITORS AND METHODS OF USE THEREOF ALVINE PHARMACEUTICALS, INC. (US) 2007-05-03 WO disclosed
EP-1362579-B1 Agent for dyeing keratinous fibres HENKEL KGAA (DE) 2006-05-24 EP disclosed
EP-1362579-A1 Agent for dyeing keratinous fibres Henkel Kommanditgesellschaft auf Aktien (DE) 2003-11-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071197-A1 BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS LTC4S, LTB4R2, LTB4R TGM2 2255/4885MAOB 57/4885MAOA 131/4885
US-20090220554-A1 Transglutaminase Inhibitors and Methods of Use Thereof TGM2, TGM3, TGM1 TGM2 1/4885MAOB 267/4885MAOA 436/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.