Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 3/20 | 0.47 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | PYGM | P11217 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1465581 | 0.88 | GAA (0.41) | KDM4EPOLBGAAMAPTLMNA | |
| SCHEMBL1074763 | 0.83 | — | — | |
| SCHEMBL1074899 | 0.83 | NPC1 (0.48) | AKR1C2AKR1C1KDM4EPOLBLMNA | |
| SCHEMBL1467336 | 0.77 | LMNA (0.44) | LMNA | |
| SCHEMBL22097618 | 0.77 | PLK1 (0.55) | PLK1KDM4EGAAMAPTHPGD | |
| SCHEMBL24515570 | 0.75 | KDM4E (0.62) | KDM4EPOLBPYGMHPGDKMT2A | |
| SCHEMBL1025243 | 0.75 | HDAC3 (0.50) | KDM4EPOLBPYGMGAAMAPT | |
| SCHEMBL4566591 | 0.75 | CNR2 (0.41) | PLK1PLK3KDM4EGAAMAPT | |
| SCHEMBL2436534 | 0.74 | L3MBTL1 (0.65) | POLBMEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL7150993 | 0.73 | HTR7 (0.57) | POLBMAPTHPGDSMN1; SMN2MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274280-A2 | BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS | Biolipox AB (SE) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009127822-A2 | BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS | BIOLIPOX AB (SE) | 2009-10-22 | — | — | WO | disclosed |