SCHEMBL10760505

SCHEMBL10760505

CN(C(=O)c1cc(-c2ccccc2)nc2ccccc12)C1CCCCC1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.62
DHODH Q02127 3/20 0.58
KDM4E B2RXH2 2/20 0.56
LMNA P02545 2/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
PDE10A Q9Y233 1/20 0.56
NPC1 O15118 1/20 0.53
RAB9A P51151 1/20 0.53
TACR3 P29371 1/20 0.53
HPGD P15428 1/20 0.51
WNK1 Q9H4A3 1/20 0.51
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
CYP3A4 P08684 2/20 0.50
GAA P10253 1/20 0.50
HTR3E A5X5Y0 1/20 0.49
HTR3B O95264 1/20 0.49
HTR3A P46098 1/20 0.49
HTR3D Q70Z44 1/20 0.49
HTR3C Q8WXA8 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10760283 0.81 TSHR (0.72) TSHRDHODHKDM4ELMNASMN1; SMN2
Methane SCHEMBL10505710 0.79 BACE1 (0.61) TSHRDHODHKDM4ELMNASMN1; SMN2
SCHEMBL10675279 0.78 TSHR (0.47) TSHRDHODHKDM4ELMNASMN1; SMN2
SCHEMBL10763834 0.77 TSHR (0.67) TSHRDHODHKDM4ELMNASMN1; SMN2
SCHEMBL29859762 0.77 TSHR (1.00) TSHRDHODHKDM4ELMNASMN1; SMN2
SCHEMBL13209768 0.76 TSHR (0.66) TSHRDHODHKDM4ELMNASMN1; SMN2
SCHEMBL14970878 0.76 KDM4E (0.75) KDM4ELMNASMN1; SMN2RAB9AMEN1
SCHEMBL10390584 0.75 TSHR (0.64) TSHRDHODHKDM4ELMNASMN1; SMN2
SCHEMBL10608979 0.75 L3MBTL1 (0.57) TSHRKDM4ELMNASMN1; SMN2NPC1
SCHEMBL10758382 0.75 TSHR (0.67) TSHRDHODHKDM4ELMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4711890-A TREATMENT OF ANXIETY STATES OR OF PULMONARY, RENAL, CIRCULATORY OF CARDIOVASCULAR DISORDERS RHONE-POULENC SANTE (FR) 1987-12-08 US disclosed
US-4684652-A TREATING ANXIETY OR CARDIOVASCULAR DISORDERS RHONE-POULENC SANTE (FR) 1987-08-04 US disclosed