Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 5/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10778414 | 0.80 | PDE3B (0.40) | HTR7KDM4EALDH1A1TP53PDE3B | |
| SCHEMBL10775224 | 0.78 | MEN1 (0.48) | KDM4EALDH1A1GAAPKMMEN1 | |
| SCHEMBL10957936 | 0.77 | CYP1A2 (0.47) | HTR7MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL10750346 | 0.73 | ADRA2A (0.42) | HTR7MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL10767817 | 0.73 | ALDH1A1 (0.43) | HTR7MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL10957578 | 0.72 | ADORA3 (0.42) | KDM4EALDH1A1TP53PDE3BPDE3A | |
| SCHEMBL10958050 | 0.71 | ADRA2A (0.39) | HTR7MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL10956542 | 0.70 | ALDH1A1 (0.53) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL10958062 | 0.68 | KDM4E (0.40) | MAPTKDM4EALDH1A1GAAKMT2A | |
| SCHEMBL17522756 | 0.66 | MAPT (0.53) | MAPTKDM4EALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227451-A2 | 5,6-Dialkoxy-4-imino-2 (1H)quinazolinone derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-07-01 | — | — | EP | disclosed |
| US-4668787-A | CARDIOTONIC | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-05-26 | — | — | US | disclosed |