Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.38 |
| ▸ | NQO2 | P16083 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10957578 | 0.85 | ADORA3 (0.42) | PDE3BPDE3ABRD4CYP19A1NQO2 | |
| SCHEMBL10772349 | 0.80 | HTR7 (0.40) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL10780670 | 0.73 | CYP19A1 (0.40) | PDE3BPDE3ACYP19A1NQO2KDM4E | |
| SCHEMBL10957936 | 0.72 | CYP1A2 (0.47) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL10767817 | 0.72 | ALDH1A1 (0.43) | PDE3BPDE3AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL10750346 | 0.72 | ADRA2A (0.42) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL10750340 | 0.70 | PDE3B (0.39) | PDE3BPDE3ACYP19A1NQO2KDM4E | |
| SCHEMBL7024462 | 0.70 | PDE3B (0.49) | PDE3BPDE3ACYP19A1NQO2KDM4E | |
| SCHEMBL13015482 | 0.69 | PDE3B (0.40) | PDE3BPDE3ABRD4CYP19A1NQO2 | |
| SCHEMBL10956542 | 0.69 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4668787-A | CARDIOTONIC | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-05-26 | — | — | US | claimed |