Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 12/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 11/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 11/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.41 |
| ▸ | MGMT | P16455 | 6/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2,6-Diaminopurine SCHEMBL6241914 | 1.00 | PDPK1 (0.59) | PDPK1GDACDK2DPP4CDK1 | |
| 2,6-Diaminopurine SCHEMBL2934952 | 1.00 | PDPK1 (0.59) | PDPK1GDACDK2DPP4CDK1 | |
| Ribose (Furanose) SCHEMBL4284369 | 0.89 | HIF1A (0.46) | PDPK1GDADPP4ADORA2AADORA1 | |
| Ribose (Furanose) SCHEMBL2935366 | 0.88 | PDPK1 (0.42) | PDPK1GDACDK2CDK1CCNB1 | |
| 6-Chloroguanine SCHEMBL7208346 | 0.88 | DPP4 (0.61) | PDPK1GDACDK2DPP4CDK1 | |
| Methylguanine SCHEMBL34851 | 0.84 | CDK1 (0.51) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| Adenine SCHEMBL580228 | 0.83 | PI4KA (0.58) | CDK2DPP4CDK1ADORA2AADORA1 | |
| Adenine SCHEMBL7746165 | 0.83 | PI4KA (0.58) | CDK2DPP4CDK1ADORA2AADORA1 | |
| Adenine SCHEMBL38386 | 0.83 | PI4KA (0.58) | CDK2DPP4CDK1ADORA2AADORA1 | |
| Adenine SCHEMBL7624128 | 0.83 | PI4KA (0.58) | CDK2DPP4CDK1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1043997-C | 2,6-diaminopurine derivatives | GLAXO GROUP LTD (GB) | 1999-07-07 | — | — | CN | disclosed |
| CN-1119440-A | 2,6-diaminopurine derivatives | GLAXO GROUP LTD (GB) | 1996-03-27 | — | — | CN | disclosed |
| EP-0233493-A2 | Process for producing ribonucleosides | Yamasa Shoyu Kabushiki Kaisha (JP) | 1987-08-26 | — | — | EP | disclosed |