2,6-Diaminopurine

2,6-Diaminopurine

SCHEMBL2934952

Nc1nc(N)c2[nH]cnc2n1.OC[C@H]1OC(O)[C@@H](O)[C@@H]1O

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.59
GDA Q9Y2T3 1/20 0.59
CDK2 P24941 12/20 0.42
DPP4 P27487 1/20 0.42
CDK1 P06493 11/20 0.41
CCNB1 P14635 11/20 0.41
CCNA2 P20248 11/20 0.41
CCNA1 P78396 11/20 0.41
MGMT P16455 6/20 0.40
MAP3K5 Q99683 2/20 0.40
CYP1A2 P05177 1/20 0.39
PIN1 Q13526 2/20 0.39
ADORA2A P29274 1/20 0.39
ADORA1 P30542 1/20 0.39
GMNN O75496 1/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38
NFKB1 P19838 1/20 0.38
DNMT1 P26358 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2,6-Diaminopurine SCHEMBL6241914 1.00 PDPK1 (0.59) PDPK1GDACDK2DPP4CDK1
2,6-Diaminopurine SCHEMBL10774603 1.00 PDPK1 (0.59) PDPK1GDACDK2DPP4CDK1
Ribose (Furanose) SCHEMBL4284369 0.89 HIF1A (0.46) PDPK1GDADPP4ADORA2AADORA1
Ribose (Furanose) SCHEMBL2935366 0.88 PDPK1 (0.42) PDPK1GDACDK2CDK1CCNB1
6-Chloroguanine SCHEMBL7208346 0.88 DPP4 (0.61) PDPK1GDACDK2DPP4CDK1
Methylguanine SCHEMBL34851 0.84 CDK1 (0.51) CDK2CDK1CCNB1CCNA2CCNA1
Adenine SCHEMBL38386 0.83 PI4KA (0.58) CDK2DPP4CDK1ADORA2AADORA1
Adenine SCHEMBL7746165 0.83 PI4KA (0.58) CDK2DPP4CDK1ADORA2AADORA1
Adenine SCHEMBL580228 0.83 PI4KA (0.58) CDK2DPP4CDK1ADORA2AADORA1
Adenine SCHEMBL7624128 0.83 PI4KA (0.58) CDK2DPP4CDK1ADORA2AADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024082546-A1 METHOD FOR BIOSYNTHESIS OF ARABINONUCLEOSIDE BY ONE-POT METHOD, AND COMPOSITION 凯莱英生命科学技术(天津)有限公司 2024-04-25 WO claimed
CN-115896215-A Method and composition for one-pot biosynthesis of arabinoside nucleosides 凯莱英生命科学技术(天津)有限公司 2023-04-04 CN claimed
US-20060094869-A1 Selective process for producing an anomer of a 1-phosphorylated saccharide derivative and process for producing a nucleoside MITSUI CHEMICALS, INC. (JP) 2006-05-04 US claimed
US-20020193314-A1 Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside MITSUI CHEMICALS, INC. (JP) 2002-12-19 US claimed
EP-1178051-A2 PROCESS FOR SELECTIVELY PRODUCING 1-PHOSPHORYLATED SUGAR DERIVATIVE ANOMER AND PROCESS FOR PRODUCING NUCLEOSIDE Mitsui Chemicals, Inc. (JP) 2002-02-06 EP claimed
WO-2024082546-A1 METHOD FOR BIOSYNTHESIS OF ARABINONUCLEOSIDE BY ONE-POT METHOD, AND COMPOSITION 凯莱英生命科学技术(天津)有限公司 2024-04-25 WO disclosed
CN-115896215-A Method and composition for one-pot biosynthesis of arabinoside nucleosides 凯莱英生命科学技术(天津)有限公司 2023-04-04 CN disclosed
EP-1925675-B1 Process for production of nucleoside compound MITSUI CHEMICALS INC (JP) 2010-02-03 EP disclosed
EP-1338654-B1 PROCESS FOR PRODUCING NUCLEOSIDE COMPOUND MITSUI CHEMICALS INC (JP) 2008-10-15 EP disclosed
EP-1925675-A1 Process for production of nucleoside compound Mitsui Chemicals, Inc. (JP) 2008-05-28 EP disclosed
US-20060094869-A1 Selective process for producing an anomer of a 1-phosphorylated saccharide derivative and process for producing a nucleoside MITSUI CHEMICALS, INC. (JP) 2006-05-04 US disclosed
US-7038039-B2 Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside MITSUI CHEMICALS, INC. (JP) 2006-05-02 US disclosed
EP-1179598-B1 PROCESS FOR PRODUCING NUCLEOSIDE COMPOUND MITSUI CHEMICALS INC (JP) 2005-08-10 EP disclosed
US-20040219646-A1 Process for producing nucleoside compound MITSUI CHEMICALS, INC. (JP) 2004-11-04 US disclosed
CN-1476484-A Process for producing nucleoside compound 三井化学株式会社 2004-02-18 CN disclosed
EP-1338654-A1 PROCESS FOR PRODUCING NUCLEOSIDE COMPOUND Mitsui Chemicals, Inc. (JP) 2003-08-27 EP disclosed
US-20020193314-A1 Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside MITSUI CHEMICALS, INC. (JP) 2002-12-19 US disclosed
EP-1179598-A1 PROCESS FOR PRODUCING NUCLEOSIDE COMPOUND Mitsui Chemicals, Inc. (JP) 2002-02-13 EP disclosed
EP-1178051-A2 PROCESS FOR SELECTIVELY PRODUCING 1-PHOSPHORYLATED SUGAR DERIVATIVE ANOMER AND PROCESS FOR PRODUCING NUCLEOSIDE Mitsui Chemicals, Inc. (JP) 2002-02-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060094869-A1 Selective process for producing an anomer of a 1-phosphorylated saccharide derivative and process for producing a nucleoside PNP, MTAP, GALE PDPK1 253/4885GDA 248/4885CDK2 760/4885
US-20020193314-A1 Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside PNP, GALE, MTAP PDPK1 191/4885GDA 247/4885CDK2 730/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.