Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.71 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.71 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL10790429 | 1.00 | PGR (0.71) | PGRTDP1NR3C1LMNAPDE4D | |
| Potassium Ion SCHEMBL10794962 | 0.93 | PGR (0.71) | PGRTDP1NR3C1LMNAPDE4D | |
| Potassium Ion SCHEMBL10790659 | 0.93 | PGR (0.71) | PGRTDP1NR3C1LMNAPDE4D | |
| SCHEMBL3354656 | 0.91 | PGR (0.58) | PGRTDP1NR3C1LMNAPDE4D | |
| SCHEMBL3359670 | 0.91 | PGR (0.58) | PGRTDP1NR3C1LMNAPDE4D | |
| SCHEMBL11507445 | 0.86 | PGR (0.54) | PGRTDP1NR3C1LMNAPDE4D | |
| SCHEMBL11506730 | 0.86 | PGR (0.54) | PGRTDP1NR3C1LMNAPDE4D | |
| SCHEMBL3243156 | 0.85 | PGR (0.53) | PGRTDP1NR3C1LMNAPDE4D | |
| SCHEMBL5200871 | 0.85 | PGR (0.53) | PGRTDP1NR3C1LMNAPDE4D | |
| SCHEMBL13830641 | 0.85 | PGR (0.53) | PGRTDP1NR3C1LMNAPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0131899-B1 | SALTS OF 15,16-METHYLENE-17-ALPHA-PREGNA-4,6-DIENE-21-CARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | SCHERING AKTIENGESELLSCHAFT (DE) | 1987-11-25 | — | — | EP | claimed |