Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.74 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | ARG2 | P78540 | 4/20 | 0.47 |
| ▸ | ARG1 | P05089 | 3/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 3/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL16341935 | 0.95 | GSR (0.71) | GSRAPPARG2ARG1PMP22 | |
| Lysine SCHEMBL16341936 | 0.95 | GSR (0.71) | GSRAPPARG2ARG1PMP22 | |
| Lysine SCHEMBL14742303 | 0.91 | GSR (0.67) | GSRAPPARG2ARG1PMP22 | |
| Lysine SCHEMBL14742302 | 0.91 | GSR (0.67) | GSRAPPARG2ARG1PMP22 | |
| Lysine SCHEMBL272788 | 0.90 | GSR (0.83) | GSRARG2ARG1PMP22RNPEP | |
| Lysine SCHEMBL31545754 | 0.90 | GSR (0.83) | GSRARG2ARG1PMP22RNPEP | |
| Lysine SCHEMBL272789 | 0.90 | GSR (0.83) | GSRARG2ARG1PMP22RNPEP | |
| Lysine SCHEMBL30002814 | 0.90 | GSR (0.83) | GSRARG2ARG1PMP22RNPEP | |
| Lysine SCHEMBL8201264 | 0.90 | GSR (0.83) | GSRARG2ARG1PMP22RNPEP | |
| Lysine SCHEMBL28324668 | 0.90 | GSR (0.83) | GSRARG2ARG1PMP22RNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4699756-B2 | — | — | 2011-06-15 | — | — | JP | claimed |
| US-7824928-B2 | Hydrophilic chemiluminescent acridinium labeling reagents | QUEST DIAGNOSTICS INVESTMENTS INCORPORATED (US) | 2010-11-02 | — | — | US | claimed |
| US-20080199973-A1 | HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS | QUEST DIAGNOSTICS INVESTMENTS INCORPORATED | 2008-08-21 | — | — | US | claimed |
| EP-1539702-A4 | HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS | QUEST DIAGNOSTICS INVEST INC (US) | 2005-09-07 | — | — | EP | claimed |
| EP-1539702-A2 | HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS | Quest Diagnostics Investments Incorporated (US) | 2005-06-15 | — | — | EP | claimed |
| WO-2004018418-A2 | HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS | QUEST DIAGNOSTICS INVESTMENTS INCORPORATED (US) | 2004-03-04 | — | — | WO | claimed |
| US-20040038294-A1 | Comprises hydrophilic sulfoalkyl substituents/linkers which offset hydrophobicity of acridinium ring system; improved attachment with antibody/handling | QUEST DIAGNOSTIC INVESTMENTS INCORPORATED | 2004-02-26 | — | — | US | claimed |
| US-8034636-B2 | Hydrophilic chemiluminescent acridinium labeling reagents | QUEST DIAGNOSTICS INVESTMENTS INCORPORATED (US) | 2011-10-11 | — | — | US | disclosed |
| US-20110014721-A1 | HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS | QUEST DIAGNOSTICS INVESTMENTS INCORPORATED | 2011-01-20 | — | — | US | disclosed |
| US-7824928-B2 | Hydrophilic chemiluminescent acridinium labeling reagents | QUEST DIAGNOSTICS INVESTMENTS INCORPORATED (US) | 2010-11-02 | — | — | US | disclosed |
| US-20080199973-A1 | HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS | QUEST DIAGNOSTICS INVESTMENTS INCORPORATED | 2008-08-21 | — | — | US | disclosed |
| US-7297555-B2 | Hydrophilic chemiluminescent acridinium labeling reagents | QUEST DIAGNOSTICS INVESTMENTS INCORPORATED (US) | 2007-11-20 | — | — | US | disclosed |
| US-20050255528-A1 | Hydrophilic chemiluminescent acridinium labeling reagents | QUEST DIAGNOSTICS INVESTMENTS INCORPORATED | 2005-11-17 | — | — | US | disclosed |
| EP-1539702-A4 | HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS | QUEST DIAGNOSTICS INVEST INC (US) | 2005-09-07 | — | — | EP | disclosed |
| US-6924154-B2 | Hydrophilic chemilumescent acridinium labeling reagents | QUEST DIAGNOSTICS INVESTMENTS INCORPORATED (US) | 2005-08-02 | — | — | US | disclosed |
| EP-1539702-A2 | HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS | Quest Diagnostics Investments Incorporated (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018418-A2 | HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS | QUEST DIAGNOSTICS INVESTMENTS INCORPORATED (US) | 2004-03-04 | — | — | WO | disclosed |
| US-20040038294-A1 | Comprises hydrophilic sulfoalkyl substituents/linkers which offset hydrophobicity of acridinium ring system; improved attachment with antibody/handling | QUEST DIAGNOSTIC INVESTMENTS INCORPORATED | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080199973-A1 | HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS | CTH, CBS, AHCY | GSR 295/4885APP 755/4885ARG2 3224/4885 |
| US-20110014721-A1 | HYDROPHILIC CHEMILUMINESCENT ACRIDINIUM LABELING REAGENTS | CTH, CBS, AHCY | GSR 295/4885APP 755/4885ARG2 3224/4885 |
| US-20050255528-A1 | Hydrophilic chemiluminescent acridinium labeling reagents | CTH, CBS, AHCY | GSR 295/4885APP 755/4885ARG2 3224/4885 |
| US-20040038294-A1 | Comprises hydrophilic sulfoalkyl substituents/linkers which offset hydrophobicity of acridinium ring system; improved attachment with antibody/handling | CTH, CBS, TST | GSR 841/4885APP 994/4885ARG2 4123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.