Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 14/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 1.00 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.79 |
| ▸ | MEN1 | O00255 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.79 |
| ▸ | GLA | P06280 | 1/20 | 0.79 |
| ▸ | HPGD | P15428 | 1/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.79 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL10807030 | 0.89 | ADORA2B (0.81) | ADORA2BADORA3ADORA2AKDM4EMEN1 | |
| SCHEMBL1321892 | 0.88 | ADORA2B (1.00) | ADORA2BADORA3ADORA2AKDM4EMEN1 | |
| SCHEMBL10806711 | 0.87 | ADORA2B (0.98) | ADORA2BADORA3ADORA2AKDM4EMEN1 | |
| SCHEMBL14129146 | 0.85 | ADORA2B (0.94) | ADORA2BADORA3ADORA2AKDM4EMEN1 | |
| SCHEMBL14564546 | 0.84 | ADORA2B (0.79) | ADORA2BADORA3ADORA2AKDM4EMEN1 | |
| SCHEMBL1948455 | 0.83 | ADORA2B (1.00) | ADORA2BADORA3ADORA2AKDM4EMEN1 | |
| SCHEMBL7318202 | 0.83 | ADORA2B (1.00) | ADORA2BADORA3ADORA2AKDM4EMEN1 | |
| SCHEMBL661108 | 0.83 | ADORA2B (1.00) | ADORA2BADORA3ADORA2AKDM4EMEN1 | |
| SCHEMBL6794235 | 0.82 | ADORA1 (0.73) | ADORA2BADORA3ADORA2AKDM4EMEN1 | |
| SCHEMBL7311472 | 0.81 | ADORA2B (0.71) | ADORA2BADORA3ADORA2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0092398-B1 | SUBSTITUTED 8-PHENYLXANTHINES | WARNER-LAMBERT COMPANY (US) | 1987-03-25 | — | — | EP | disclosed |
| US-4452788-A | BRONCHODILATORS | WARNER-LAMBERT COMPANY (US) | 1984-06-05 | — | — | US | disclosed |
| EP-0092398-A1 | Substituted 8-phenylxanthines | WARNER-LAMBERT COMPANY (US) | 1983-10-26 | — | — | EP | disclosed |