Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10818337 | 0.76 | KMT2A (0.37) | MEN1KMT2AKCNH2ALDH1A1TDP1 | |
| SCHEMBL4949768 | 0.74 | GPR84 (0.47) | MEN1KMT2AKCNH2CYP1A2ALDH1A1 | |
| SCHEMBL10816555 | 0.72 | MEN1 (0.37) | MEN1KMT2AKCNH2ALDH1A1TDP1 | |
| SCHEMBL3662375 | 0.72 | DHFR (0.45) | MEN1KMT2AKCNH2ALDH1A1TDP1 | |
| SCHEMBL10815973 | 0.72 | MEN1 (0.37) | MEN1KMT2APTGS2KCNH2ALDH1A1 | |
| SCHEMBL15305982 | 0.70 | ALOX5 (0.42) | ALOX5PTGS2PDE10AALDH1A1MAPT | |
| SCHEMBL3265562 | 0.69 | MEN1 (0.39) | MEN1KMT2APTGS2KCNH2ALDH1A1 | |
| SCHEMBL10858339 | 0.69 | MEN1 (0.35) | MEN1KMT2AKCNH2ALDH1A1TDP1 | |
| SCHEMBL19625907 | 0.68 | KCNH2 (0.46) | MEN1KMT2AKCNH2ALDH1A1THRB | |
| SCHEMBL26393934 | 0.67 | CASP3 (0.51) | MEN1KMT2APTGS2CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0088593-B1 | 1,2,4-TRIAZINE AND PYRAZINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1987-05-27 | — | — | EP | disclosed |
| EP-0088593-A2 | 1,2,4-Triazine and pyrazine derivatives | ELI LILLY AND COMPANY (US) | 1983-09-14 | — | — | EP | disclosed |