Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4949768 | 0.77 | GPR84 (0.47) | MEN1KMT2AKCNH2ALDH1A1TDP1 | |
| SCHEMBL3662375 | 0.75 | DHFR (0.45) | MEN1KMT2AKCNH2ALDH1A1TDP1 | |
| SCHEMBL10815973 | 0.75 | MEN1 (0.37) | MEN1KMT2AKCNH2ALDH1A1GPR84 | |
| SCHEMBL10818337 | 0.75 | KMT2A (0.37) | MEN1KMT2AKCNH2ALDH1A1TDP1 | |
| SCHEMBL3265562 | 0.72 | MEN1 (0.39) | MEN1KMT2AKCNH2ALDH1A1TDP1 | |
| SCHEMBL10858339 | 0.72 | MEN1 (0.35) | MEN1KMT2AKCNH2ALDH1A1TDP1 | |
| SCHEMBL10816526 | 0.72 | MEN1 (0.35) | MEN1KMT2AKCNH2ALDH1A1TDP1 | |
| SCHEMBL19625907 | 0.70 | KCNH2 (0.46) | MEN1KMT2AKCNH2ALDH1A1PKM | |
| SCHEMBL11109583 | 0.69 | L3MBTL1 (0.36) | MEN1KMT2AKCNH2ALDH1A1TDP1 | |
| SCHEMBL5138095 | 0.69 | HRH3 (0.41) | MEN1KMT2AKCNH2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105601624-B | A kind of 1,2,4- triazines-coumarin type compound and its preparation method and purposes | 南京双科医药开发有限公司 | 2018-05-22 | — | — | CN | claimed |
| EP-0088593-B1 | 1,2,4-TRIAZINE AND PYRAZINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1987-05-27 | — | — | EP | disclosed |
| US-4585861-A | ACTIVATORS OF GAMMA-AMINOBUTYRIC ACID AND BENZODIAZEPINE BINDING | ELI LILLY AND COMPANY (US) | 1986-04-29 | — | — | US | disclosed |
| US-4513135-A | GAMMA-AMINOBUTYRIC ACID BINDING AGTIVATORS | ELI LILLY AND COMPANY (US) | 1985-04-23 | — | — | US | disclosed |
| EP-0088593-A2 | 1,2,4-Triazine and pyrazine derivatives | ELI LILLY AND COMPANY (US) | 1983-09-14 | — | — | EP | disclosed |
| US-4318911-A | 5,6-Diaryl-1,2,4-triazines as topical antithrombotic agents | ELI LILLY AND COMPANY (US) | 1982-03-09 | — | — | US | disclosed |
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |
| US-4018923-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |
| US-4013654-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1977-03-22 | — | — | US | disclosed |
| US-4008232-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1977-02-15 | — | — | US | disclosed |
| US-3979516-A | Anti-inflammatory 3-amino-5,6-diaryl-1,2,4-triazines | ELI LILLY AND COMPANY (US) | 1976-09-07 | — | — | US | disclosed |
| US-3948894-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1976-04-06 | — | — | US | disclosed |