Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1082740 | 1.00 | CA1 (0.37) | CA1CA9BBOX1ALDH1A1LMNA | |
| Acrylic Acid SCHEMBL7154952 | 0.86 | TSHR (0.37) | BBOX1ALDH1A1LMNA | |
| SCHEMBL10457405 | 0.80 | BBOX1 (0.30) | BBOX1 | |
| Acetic Acid SCHEMBL4557323 | 0.80 | CA1 (0.47) | CA1BBOX1ALDH1A1LMNA | |
| Fumaric Acid SCHEMBL3166085 | 0.78 | CA1 (0.43) | CA1CA9BBOX1 | |
| Acetic Acid SCHEMBL2362050 | 0.78 | — | — | |
| Thioglycolic Acid SCHEMBL1077110 | 0.76 | BBOX1 (0.32) | BBOX1 | |
| Fumaric Acid SCHEMBL11691727 | 0.76 | BBOX1 (0.39) | CA1CA9BBOX1ALDH1A1LMNA | |
| Fumaric Acid SCHEMBL19667848 | 0.75 | CA1 (0.41) | CA1CA9BBOX1 | |
| Fumaric Acid SCHEMBL21815723 | 0.74 | CA1 (0.45) | CA1CA9BBOX1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170058118-A1 | STABILIZERS FOR POLYMERS CONTAINING ALIPHATICALLY-BOUND BROMINE | DCOMCO, INC. | 2017-03-02 | — | — | US | claimed |
| WO-2008030399-A1 | STABILIZED EXTRUDED ALKENYL AROMATIC POLYMER FOAMS AND PROCESSES FOR EXTRUDING STABILIZED ALKENYL AROMATIC POLYMER FOAMS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2008-03-13 | — | — | WO | claimed |
| US-20080064774-A1 | Stabilized extruded alkenyl aromatic polymer foams and processes for extruding stabilized alkenyl aromatic polymer foams | STOBBY WILLIAM G | 2008-03-13 | — | — | US | claimed |
| EP-1263869-B1 | HALOGEN CONTAINING POLYMER COMPOUNDS CONTAINING MODIFIED ZEOLITE STABILIZERS | NOVEON IP HOLDINGS CORP (US) | 2006-03-29 | — | — | EP | claimed |
| US-20030166752-A1 | Melt processability; heat resistance | NOVEON IP HOLDINGS CORP. | 2003-09-04 | — | — | US | claimed |
| JP-2003525990-A | — | — | 2003-09-02 | — | — | JP | claimed |
| US-6531526-B1 | Mixing stabilizer agents comprising group IV compounds and zeolite 4A, with polyvinyl chloride to form compounds having heat resistance, impact and tensile strength; waterproofing | NOVEON IP HOLDINGS CORP. | 2003-03-11 | — | — | US | claimed |
| EP-1263869-A1 | HALOGEN CONTAINING POLYMER COMPOUNDS CONTAINING MODIFIED ZEOLITE STABILIZERS | Noveon IP Holdings Corp. (US) | 2002-12-11 | — | — | EP | claimed |
| WO-2001066638-A1 | HALOGEN CONTAINING POLYMER COMPOUNDS CONTAINING MODIFIED ZEOLITE STABILIZERS | NOVEON IP HOLDINGS CORP. (US) | 2001-09-13 | — | — | WO | claimed |
| US-5002702-A | For polypropylene fibers or foils | SANDOZ LTD. (CH) | 1991-03-26 | — | — | US | claimed |
| US-4357434-A | HYDROXY-MERCAPTAN COMPOUNDS | AJINOMOTO COMPANY INCORPORATED (JP) | 1982-11-02 | — | — | US | claimed |
| JP-11310679-A | — | — | None | — | — | JP | disclosed |
| JP-9174645-A | — | — | None | — | — | JP | disclosed |
| US-20230036408-A1 | SYNERGISTIC FLAME & SMOKE SUPPRESSING COMPOSITION FOR PLASTIC APPLICATIONS | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2023-02-02 | — | — | US | disclosed |
| EP-2448975-B1 | BROMINATED AND EPOXIDIZED FLAME RETARDANTS | DDP SPECIALTY ELECTRONIC MATERIALS US LLC (US) | 2021-08-11 | — | — | EP | disclosed |
| US-5002702-A | For polypropylene fibers or foils | SANDOZ LTD. (CH) | 1991-03-26 | — | — | US | disclosed |
| US-4434260-A | Thermoplastic resin shaping with olefin/maleimide copolymer lubricant | AKZONA, INC. (US) | 1984-02-28 | — | — | US | disclosed |
| US-4357434-A | HYDROXY-MERCAPTAN COMPOUNDS | AJINOMOTO COMPANY INCORPORATED (JP) | 1982-11-02 | — | — | US | disclosed |
| US-4357434-A | HYDROXY-MERCAPTAN COMPOUNDS | AJINOMOTO COMPANY INCORPORATED (JP) | 1982-11-02 | — | — | US | disclosed |
| US-4244899-A | ACTIVATOR IN THE FORM OF A PLASTISOL OR ORGANOSOL CONTAINING POLYVINYL CHLORIDE | CONGOLEUM CORPORATION (US) | 1981-01-13 | — | — | US | disclosed |