Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1083637 | 0.99 | MAPK1 (0.39) | CA12CA7CA9CA14PDE1A | |
| SCHEMBL8441398 | 0.81 | ALDH1A1 (0.43) | PDE1APDE1BPDE1CALDH1A1TDP1 | |
| SCHEMBL1083035 | 0.79 | GABRA1 (0.43) | PDE1APDE1BPDE1CALDH1A1TDP1 | |
| SCHEMBL6518667 | 0.71 | ALDH1A1 (0.43) | CA12CA7CA9CA14ALDH1A1 | |
| SCHEMBL7684558 | 0.67 | ALDH1A1 (0.61) | ALDH1A1KDM4ECTNNB1HTTSMN1; SMN2 | |
| SCHEMBL27699241 | 0.66 | KDM4E (0.55) | ALDH1A1TDP1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL4253158 | 0.65 | PRCP (0.55) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL28190881 | 0.64 | ALDH1A1 (0.43) | ALDH1A1TDP1MAPK1CYP11B1CYP11B2 | |
| SCHEMBL4953295 | 0.64 | CA12 (0.52) | CA12CA7CA9CA14ALDH1A1 | |
| SCHEMBL28970084 | 0.64 | MTNR1A (0.53) | CA12CA7CA9CA14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271627-A1 | ETOMIDATE ANALOGUES WITH IMPROVED PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES | The General Hospital Corporation (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009146024-A1 | ETOMIDATE ANALOGUES WITH IMPROVED PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES | THE GENERAL HOSPITAL CORPORATION (US) | 2009-12-03 | — | — | WO | disclosed |