Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 8/20 | 0.47 |
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | DRD5 | P21918 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 5/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10835486 | 0.89 | DRD3 (0.64) | DRD3DRD2DRD5HTR7DRD1 | |
| Hydrochloric Acid SCHEMBL10835779 | 0.88 | DRD3 (0.62) | DRD3DRD2DRD5HTR7DRD1 | |
| SCHEMBL10835105 | 0.87 | DRD3 (0.59) | DRD3DRD2DRD5HTR7DRD1 | |
| SCHEMBL10835894 | 0.87 | DRD2 (0.45) | DRD3DRD2DRD5HTR7DRD1 | |
| SCHEMBL10834807 | 0.87 | DRD3 (0.66) | DRD3DRD2DRD5HTR7DRD1 | |
| Hydrochloric Acid SCHEMBL10836043 | 0.85 | HTR1A (0.57) | DRD3DRD2DRD5HTR7DRD1 | |
| SCHEMBL10834571 | 0.85 | DRD2 (0.52) | DRD3DRD2HTR7ADRA1BKDM4E | |
| SCHEMBL10834926 | 0.84 | TRPV4 (0.46) | DRD3DRD2DRD5HTR7HTR1A | |
| SCHEMBL10835699 | 0.83 | DRD2 (0.54) | DRD3DRD2DRD5HTR7HTR1A | |
| SCHEMBL10834441 | 0.83 | DRD3 (0.58) | DRD3DRD2DRD5HTR7DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4585773-A | DIURETIC, HYPOTENSIVE | BRISTOL-MYERS COMPANY (US) | 1986-04-29 | — | — | US | claimed |
| US-4585773-A | DIURETIC, HYPOTENSIVE | BRISTOL-MYERS COMPANY (US) | 1986-04-29 | — | — | US | disclosed |