Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.42 |
| ▸ | HTR1A | P08908 | 5/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.42 |
| ▸ | THRA | P10827 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10837925 | 0.99 | S1PR1 (0.43) | S1PR1ADRA1DSLC6A2SLC6A3HTR1A | |
| Water SCHEMBL10836253 | 0.99 | S1PR1 (0.43) | S1PR1ADRA1DSLC6A2SLC6A3HTR1A | |
| SCHEMBL10835787 | 0.85 | HTR1A (0.48) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL10836260 | 0.82 | S1PR1 (0.44) | S1PR1ADRA1DHTR1ATHRATHRB | |
| SCHEMBL11290166 | 0.81 | HTR1A (0.52) | SLC6A3HTR1ASLC6A4DRD2ABCB1 | |
| SCHEMBL10836259 | 0.77 | HTR1A (0.53) | ADRA1DHTR1ASLC6A4DRD2HTR1D | |
| SCHEMBL10836233 | 0.77 | HTR1A (0.56) | ADRA1DSLC6A2SLC6A3HTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL10837514 | 0.77 | DRD2 (0.51) | HTR1ASLC6A4DRD2ABCB1HTR1D | |
| SCHEMBL10838437 | 0.76 | DRD2 (0.55) | HTR1ADRD2DRD4DRD3HTR2A | |
| Hydrochloric Acid SCHEMBL10835643 | 0.76 | DRD2 (0.54) | HTR1ADRD2DRD4DRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4619932-A | CENTRAL NERVOUS SYSTEM CONTROLLERS; ANTI-SCHIZOPHRENIA AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-10-28 | — | — | US | disclosed |
| US-4567187-A | CENTRAL NERVOUS SYSTEM | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| US-4460593-A | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-17 | — | — | US | disclosed |
| US-4455422-A | ANTIHISTAMINES, CNS CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | disclosed |