Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10848510 | 0.83 | SLC2A1 (0.46) | NPC1RAB9AGAASLC2A1MAPT | |
| SCHEMBL10840990 | 0.80 | SLC2A1 (0.58) | NPC1RAB9ASLC2A1MAPTMEN1 | |
| SCHEMBL10853045 | 0.78 | ALDH1A1 (0.40) | ATMPOLBNPC1RAB9AGAA | |
| SCHEMBL10801863 | 0.77 | SLC2A1 (0.70) | POLBNPC1GAAL3MBTL1SLC2A1 | |
| SCHEMBL10847979 | 0.76 | ALDH1A1 (0.43) | NPC1RAB9AL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL10848812 | 0.74 | PDE4B (0.55) | NPC1RAB9AGAAL3MBTL1MAPT | |
| SCHEMBL28644530 | 0.71 | POLB (0.62) | ATMPOLBNPC1RAB9AGAA | |
| SCHEMBL11765789 | 0.71 | NPC1 (0.72) | ATMNPC1RAB9AGAAL3MBTL1 | |
| SCHEMBL10840308 | 0.71 | SLC2A1 (0.65) | ATMNPC1RAB9AGAAL3MBTL1 | |
| SCHEMBL10804316 | 0.70 | SLC2A1 (0.63) | POLBNPC1RAB9AL3MBTL1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | claimed |
| US-4621089-A | Pyrazolopyridine derivatives and their use in treating inflammation and allergic conditions | BEECHAM GROUP P.L.C. (GB) | 1986-11-04 | — | — | US | disclosed |
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | disclosed |