Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GLP1R | P43220 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31347005 | 0.78 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL26107861 | 0.78 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL10847105 | 0.78 | GPR35 (0.41) | ALDH1A1HSD17B10 | |
| SCHEMBL10853045 | 0.76 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL10844579 | 0.76 | ATM (0.46) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL23198681 | 0.73 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL17540948 | 0.73 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL163381 | 0.72 | SMN1; SMN2 (0.53) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL18137652 | 0.72 | GLP1R (0.50) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL23198535 | 0.72 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4621089-A | Pyrazolopyridine derivatives and their use in treating inflammation and allergic conditions | BEECHAM GROUP P.L.C. (GB) | 1986-11-04 | — | — | US | disclosed |
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | disclosed |