Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10846106 | 0.81 | HPGD (0.37) | ALDH1A1L3MBTL1HPGDKDM4EMEN1 | |
| SCHEMBL10506617 | 0.78 | SLC2A1 (0.48) | ALDH1A1HPGDLMNAKDM4EMEN1 | |
| SCHEMBL10844579 | 0.78 | ATM (0.46) | ALDH1A1L3MBTL1HPGDTDP1MEN1 | |
| SCHEMBL10847979 | 0.76 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10509852 | 0.74 | MEN1 (0.44) | ALDH1A1L3MBTL1HPGDLMNATDP1 | |
| SCHEMBL10840990 | 0.67 | SLC2A1 (0.58) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL10465572 | 0.66 | L3MBTL1 (0.63) | ALDH1A1L3MBTL1HPGDTDP1KDM4E | |
| SCHEMBL26107861 | 0.66 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1HPGDLMNAKDM4E | |
| SCHEMBL31347005 | 0.66 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1HPGDLMNAKDM4E | |
| SCHEMBL10568215 | 0.66 | SLC2A1 (0.41) | ALDH1A1HPGDLMNAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | claimed |
| US-4621089-A | Pyrazolopyridine derivatives and their use in treating inflammation and allergic conditions | BEECHAM GROUP P.L.C. (GB) | 1986-11-04 | — | — | US | disclosed |
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | disclosed |