Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 13/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 13/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11085099 | 1.00 | KCNE1 (0.34) | KCNE1KCNQ1LMNAMAPTHTT | |
| SCHEMBL10849339 | 0.80 | KDM4E (0.51) | KCNE1KCNQ1ABCC9MEN1CYP1A2 | |
| SCHEMBL11074219 | 0.80 | KDM4E (0.51) | KCNE1KCNQ1ABCC9MEN1CYP1A2 | |
| SCHEMBL10846469 | 0.80 | AKR1B1 (0.36) | KCNE1KCNQ1ABCC9ALDH1A1PKM | |
| SCHEMBL10848288 | 0.80 | KCNE1 (0.36) | KCNE1KCNQ1 | |
| SCHEMBL11072866 | 0.80 | KCNE1 (0.36) | KCNE1KCNQ1 | |
| SCHEMBL10846477 | 0.80 | AKR1B1 (0.36) | KCNE1KCNQ1ABCC9ALDH1A1PKM | |
| SCHEMBL10848198 | 0.80 | HTT (0.34) | LMNAMAPTHTTSMN1; SMN2ABCC9 | |
| SCHEMBL8088761 | 0.74 | ABCC9 (0.38) | LMNAMAPTHTTSMN1; SMN2ABCC9 | |
| Hydrochloric Acid SCHEMBL11611527 | 0.72 | KCNE1 (0.48) | KCNE1KCNQ1ABCC9MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4629734-A | HYPOTENSIVE AGENTS | BEECHAM GROUP P.L.C. (GB) | 1986-12-16 | — | — | US | claimed |
| EP-0126350-A1 | Novel compounds | BEECHAM GROUP PLC (GB) | 1984-11-28 | — | — | EP | claimed |