Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 10/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10846106 | 0.84 | HPGD (0.37) | RAB9AHPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL10847105 | 0.75 | GPR35 (0.41) | HPGDALDH1A1LMNA | |
| SCHEMBL6642124 | 0.65 | SMN1; SMN2 (0.56) | RAB9AHPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6850243 | 0.62 | SLC2A1 (0.44) | CYP1A2POLBKMT2AMAPTLMNA | |
| SCHEMBL15559343 | 0.62 | SMN1; SMN2 (0.56) | RAB9AHPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL10506617 | 0.61 | SLC2A1 (0.48) | RAB9AHPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL20278439 | 0.61 | HPGD (0.49) | RAB9AHPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8596997 | 0.61 | HTT (0.51) | RAB9AHPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7112031 | 0.61 | RAB9A (0.75) | RAB9AHPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL2152525 | 0.61 | SMN1; SMN2 (0.53) | RAB9AHPGDCYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4621089-A | Pyrazolopyridine derivatives and their use in treating inflammation and allergic conditions | BEECHAM GROUP P.L.C. (GB) | 1986-11-04 | — | — | US | disclosed |
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | disclosed |