Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10847659 | 0.84 | RAB9A (0.43) | HPGDKMT2AMEN1PKMCYP1A2 | |
| SCHEMBL10853045 | 0.81 | ALDH1A1 (0.40) | HPGDKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL10506617 | 0.77 | SLC2A1 (0.48) | HPGDKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL10507536 | 0.68 | TGFBR1 (0.40) | HPGDKMT2AMEN1PKMCYP3A4 | |
| SCHEMBL6642124 | 0.64 | SMN1; SMN2 (0.56) | HPGDKMT2AMEN1PKMCYP1A2 | |
| SCHEMBL10563794 | 0.63 | HCAR3 (0.41) | RAB9AALDH1A1KDM4E | |
| SCHEMBL10567519 | 0.62 | JAK3 (0.38) | MAPTGAA | |
| SCHEMBL10567101 | 0.62 | HPGD (0.37) | HPGD | |
| SCHEMBL15110555 | 0.62 | HPGD (0.54) | HPGDKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL10848510 | 0.62 | SLC2A1 (0.46) | HPGDRAB9ASMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | claimed |
| US-4621089-A | Pyrazolopyridine derivatives and their use in treating inflammation and allergic conditions | BEECHAM GROUP P.L.C. (GB) | 1986-11-04 | — | — | US | disclosed |
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | disclosed |