Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | IGFBP5 | P24593 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10847659 | 0.75 | RAB9A (0.43) | ALDH1A1HPGDLMNA | |
| SCHEMBL30540593 | 0.73 | KMO (0.42) | GPR35ALOX15TSHRHIF1AKMO | |
| SCHEMBL10848510 | 0.72 | SLC2A1 (0.46) | ALOX15ALDH1A1HPGDHSD17B10MGAM | |
| SCHEMBL6850243 | 0.72 | SLC2A1 (0.44) | NOS1LMNA | |
| SCHEMBL1144369 | 0.71 | TTR (0.46) | ALOX15TSHRHIF1ANOS1ALDH1A1 | |
| SCHEMBL10850431 | 0.69 | NT5E (0.42) | NOS1ALDH1A1HSD17B10 | |
| SCHEMBL4994747 | 0.67 | NAMPT (0.49) | ALOX15TSHRHIF1ANOS1ALDH1A1 | |
| SCHEMBL30483401 | 0.67 | NAMPT (0.49) | ALOX15TSHRHIF1ANOS1ALDH1A1 | |
| SCHEMBL27158053 | 0.67 | ALOX15 (0.50) | ALOX15TSHRALDH1A1HPGDHSD17B10 | |
| SCHEMBL2775988 | 0.67 | ALOX15 (0.58) | GPR35ALOX15ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4621089-A | Pyrazolopyridine derivatives and their use in treating inflammation and allergic conditions | BEECHAM GROUP P.L.C. (GB) | 1986-11-04 | — | — | US | disclosed |
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | disclosed |