Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9579195 | 0.91 | AGTR1 (0.43) | FFAR4FFAR1AGTR1AGTR2 | |
| SCHEMBL10852592 | 0.89 | FFAR4 (0.46) | FFAR4FFAR1MRGPRX4CD274 | |
| SCHEMBL10227 | 0.89 | CACNA1G (0.46) | AGTR1AGTR2PTGDR2BCL2MCL1 | |
| SCHEMBL10849715 | 0.87 | AGTR1 (0.41) | AGTR1AGTR2PTGDR2BCL2MCL1 | |
| SCHEMBL11094574 | 0.86 | PTGDR2 (0.52) | FFAR4FFAR1PTGDR2 | |
| SCHEMBL10850513 | 0.84 | AGTR1 (0.43) | AGTR1AGTR2BCL2MCL1 | |
| SCHEMBL7048392 | 0.83 | AGTR1 (0.44) | AGTR1AGTR2BCL2MCL1 | |
| SCHEMBL8954292 | 0.83 | ALDH1A1 (0.49) | AGTR1AGTR2PTGDR2BCL2MCL1 | |
| SCHEMBL10852512 | 0.82 | FFAR4 (0.45) | FFAR4FFAR1MRGPRX4PTGER1AGTR1 | |
| SCHEMBL11091674 | 0.81 | TP53 (0.53) | AGTR1AGTR2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0103647-B1 | 4-CHLORO-2-PHENYLIMIDAZOLE-5-ACETIC ACID DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1986-12-03 | — | — | EP | disclosed |
| US-4582847-A | 4-chloro-2-phenylimidazole-5-acetic acid derivatives and use as diuretics and hypotensives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-04-15 | — | — | US | disclosed |
| EP-0103647-A1 | 4-CHLORO-2-PHENYLIMIDAZOLE-5-ACETIC ACID DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1984-03-28 | — | — | EP | disclosed |