Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19655893 | 0.77 | CSNK2A2 (0.33) | L3MBTL1HTTALDH1A1 | |
| SCHEMBL17427347 | 0.72 | KDM6B (0.31) | — | |
| SCHEMBL14498872 | 0.72 | — | — | |
| SCHEMBL8407246 | 0.69 | ALDH1A1 (0.50) | L3MBTL1KDM4EGAAMAPTALDH1A1 | |
| SCHEMBL11072976 | 0.67 | PDE5A (0.40) | HTTALDH1A1 | |
| SCHEMBL4577350 | 0.67 | — | — | |
| SCHEMBL11066997 | 0.65 | MAPT (0.36) | HSD17B10MAPTALDH1A1 | |
| SCHEMBL17727039 | 0.65 | — | — | |
| SCHEMBL757019 | 0.65 | — | — | |
| SCHEMBL9879119 | 0.65 | HTT (0.48) | L3MBTL1HTTKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4600720-A | HISTAMINE H2-ANTOAGONISTS, ANTISECRETORY; THIAZOLINE, QUINAZOLINE, QUINOLINE, PYRIMIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1986-07-15 | — | — | US | disclosed |
| US-4578459-A | HISTAMINE H2-ANTAGONISTS | SMITHKLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-03-25 | — | — | US | disclosed |
| US-4537779-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-08-27 | — | — | US | disclosed |
| US-4470985-A | HISTAMINE H-2 ANTAGONISTS | SMITHKLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-09-11 | — | — | US | disclosed |
| US-4467087-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-08-21 | — | — | US | disclosed |
| US-4399142-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-08-16 | — | — | US | disclosed |
| US-4374251-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-02-15 | — | — | US | disclosed |
| US-4341787-A | ANTIHISTAMINES; ANTISECRETORY AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1982-07-27 | — | — | US | disclosed |
| US-4282221-A | Pharmacologically active compounds to inhibit H-2 histamine receptors | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-08-04 | — | — | US | disclosed |
| US-4181730-A | ANTISECRETORY AGENTS, IMIDAZOLYALKYLIMIDAZOLINONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-01-01 | — | — | US | disclosed |
| US-4153793-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-08 | — | — | US | disclosed |
| US-4104381-A | HISTAMINE INHIBITORS, ((IMIDAZOLYLALKYL)AMINO)THIADIAZINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-01 | — | — | US | disclosed |
| US-4005205-A | PYRIMIDINE COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-01-25 | — | — | US | disclosed |