Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 4/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | BCKDK | O14874 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ASIC1 | P78348 | 1/20 | 0.33 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10584615 | 0.84 | ASIC3 (0.41) | ASIC3LOXL2TBXAS1BCKDKMCL1 | |
| SCHEMBL11217390 | 0.81 | ASIC3 (0.39) | ASIC3LOXL2TBXAS1BCKDKMCL1 | |
| SCHEMBL31095709 | 0.79 | EPM2A (0.31) | — | |
| SCHEMBL10858277 | 0.79 | TBXAS1 (0.36) | TBXAS1RXFP1MAPTLMNANPC1 | |
| SCHEMBL3738095 | 0.79 | BCKDK (0.55) | ASIC3LOXL2BCKDKMAPTLMNA | |
| SCHEMBL3740573 | 0.76 | MAPK1 (0.58) | RXFP1MAPTLMNAGAAKDM4E | |
| SCHEMBL658865 | 0.74 | LOXL2 (0.69) | ASIC3LOXL2MCL1RXFP1MAPT | |
| SCHEMBL10855358 | 0.71 | TBXAS1 (0.67) | TBXAS1LMNAKDM4EALDH1A1MAPK1 | |
| SCHEMBL10855374 | 0.71 | TAAR1 (0.40) | ASIC3LOXL2TBXAS1MIFRPA1 | |
| SCHEMBL18050231 | 0.71 | MCL1 (0.71) | TBXAS1BCKDKMCL1RXFP1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073663-B1 | THROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pfizer Limited (GB) | 1986-06-18 | — | — | EP | disclosed |
| US-4590200-A | NON-INHIBITION OF PROSTACYCLIN SYNTHETASE OR CYCLO-OXYGENASE | PFIZER INC. (US) | 1986-05-20 | — | — | US | disclosed |
| US-4496572-A | Benzo-fused thromboxane synthetase inhibitors | PFIZER INC. (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0073663-A2 | Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them | Pfizer Limited (GB) | 1983-03-09 | — | — | EP | disclosed |