Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 9/20 | 0.41 |
| ▸ | ASIC1 | P78348 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10854905 | 0.86 | TAAR1 (0.38) | TAAR1ABCC8KCNJ11MIFCYP19A1 | |
| SCHEMBL10855374 | 0.81 | TAAR1 (0.40) | ASIC3TAAR1MIFADRA2AADRA2B | |
| SCHEMBL10861551 | 0.78 | TBXAS1 (0.54) | TAAR1 | |
| SCHEMBL10851678 | 0.71 | TAAR1 (0.38) | TAAR1ABCC8KCNJ11CYP19A1CYP11B1 | |
| SCHEMBL10860344 | 0.69 | TBXAS1 (0.64) | ASIC3CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL1507905 | 0.69 | TAAR1 (0.61) | TAAR1CYP19A1ADRA2AADRA2BADRA2C | |
| SCHEMBL10853507 | 0.68 | ALDH1A1 (0.43) | TAAR1 | |
| Hydrochloric Acid SCHEMBL8307737 | 0.68 | TAAR1 (0.59) | TAAR1CYP19A1ADRA2AADRA2BADRA2C | |
| SCHEMBL10858086 | 0.67 | TAAR1 (0.40) | TAAR1ADRA2AADRA2BADRA2CHTR1A | |
| SCHEMBL10856351 | 0.66 | ADRA2A (0.45) | TAAR1ABCC8KCNJ11CYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073663-B1 | THROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pfizer Limited (GB) | 1986-06-18 | — | — | EP | disclosed |
| US-4590200-A | NON-INHIBITION OF PROSTACYCLIN SYNTHETASE OR CYCLO-OXYGENASE | PFIZER INC. (US) | 1986-05-20 | — | — | US | disclosed |
| US-4496572-A | Benzo-fused thromboxane synthetase inhibitors | PFIZER INC. (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0073663-A2 | Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them | Pfizer Limited (GB) | 1983-03-09 | — | — | EP | disclosed |