Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.43 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | SPR | P35270 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10871284 | 0.89 | HTR2A (0.60) | KDM4EALDH1A1CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL10872305 | 0.89 | MTNR1A (0.50) | HTR2AMEN1KMT2AHTR1DHTR1B | |
| SCHEMBL10869866 | 0.86 | HTR2A (0.51) | HTR7ALDH1A1CYP1A2MAPTHPGD | |
| Hydrochloric Acid SCHEMBL10870609 | 0.85 | HTR2A (0.50) | HTR7ALDH1A1CYP1A2MAPTHPGD | |
| SCHEMBL10873091 | 0.77 | SMN1; SMN2 (0.49) | HTR7KDM4EALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL10873341 | 0.75 | HTR2A (0.54) | HTR7ALDH1A1LMNAHTR2AKMT2A | |
| SCHEMBL10868996 | 0.73 | MTNR1A (0.49) | HTR2AHTR1DHTR1B | |
| SCHEMBL10868207 | 0.73 | MPO (0.54) | HTR7SPRNOTUMSLC6A4 | |
| SCHEMBL10866988 | 0.73 | HTR2A (0.59) | KDM4EALDH1A1CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL27095364 | 0.72 | HTR7 (0.71) | HTR7NPSR1CYP2D6CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187619-A2 | 1,3-Disubstituted tetrahydropyridines | CIBA-GEIGY AG (CH) | 1986-07-16 | — | — | EP | disclosed |