Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434193 | 0.82 | PDE3B (0.70) | PDE3BPDE3ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10950631 | 0.77 | PDE3B (0.44) | PDE3BPDE3ATSHRSMN1; SMN2HDAC3 | |
| SCHEMBL10874712 | 0.73 | PDE3B (0.52) | PDE3BPDE3ACYP1A2CYP2C9TSHR | |
| SCHEMBL10502071 | 0.71 | ALDH1A1 (0.47) | PDE3BPDE3ALMNAMAPTNPC1 | |
| Nicoboxil SCHEMBL288321 | 0.70 | L3MBTL1 (0.84) | L3MBTL1LMNACYP1A2CYP2C9TSHR | |
| Nicoboxil SCHEMBL29475326 | 0.70 | L3MBTL1 (0.84) | L3MBTL1LMNACYP1A2CYP2C9TSHR | |
| SCHEMBL10501352 | 0.70 | PRKAB2 (0.44) | CDK2PDE3BPDE3ALMNACYP1A2 | |
| SCHEMBL10864124 | 0.70 | PDE3B (0.74) | PDE3BPDE3ACYP1A2CYP2C9TSHR | |
| SCHEMBL551716 | 0.69 | L3MBTL1 (1.00) | L3MBTL1LMNACYP1A2CYP2C9TSHR | |
| SCHEMBL10876292 | 0.68 | PDE3B (0.72) | PDE3BPDE3ALMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0065165-B1 | 5-OXYMETHYL-4-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-06-18 | — | — | EP | disclosed |
| US-4526981-A | [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-07-02 | — | — | US | disclosed |
| EP-0065165-A1 | 5-Oxymethyl-4-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-24 | — | — | EP | disclosed |