Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | ALPL | P05186 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | F2R | P25116 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10880639 | 0.81 | ALPL (0.46) | TYK2ALPLMAPTHTTALDH1A1 | |
| SCHEMBL10877847 | 0.80 | TDP1 (0.51) | ALPLHTTALDH1A1KDM4EKMT2A | |
| SCHEMBL2662445 | 0.77 | ALPL (0.61) | TYK2ALPLMAPTHTTALDH1A1 | |
| SCHEMBL1250218 | 0.77 | ALDH1A1 (0.50) | ALPLBTKMAPTALDH1A1KDM4E | |
| SCHEMBL11559491 | 0.77 | KDR (0.51) | TYK2ALPLMAPTHTTALDH1A1 | |
| SCHEMBL12310841 | 0.77 | MMP2 (0.45) | ALPLBTKALDH1A1KDM4EHPGD | |
| SCHEMBL14511140 | 0.76 | POLB (0.43) | BTKMAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL10792688 | 0.76 | JAK2 (0.42) | JAK1TYK2ALPLBTKALDH1A1 | |
| SCHEMBL10937760 | 0.75 | KIT (0.45) | ALPLMAPTHTTALDH1A1KDM4E | |
| SCHEMBL11436009 | 0.74 | NPC1 (0.44) | PIK3CAMTORMAPTHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0086340-B1 | 3-(1H-TETRAZOL-5-YL)-4(3H)-QUINAZOLINONES | THE DOW CHEMICAL COMPANY (US) | 1986-04-02 | — | — | EP | disclosed |
| US-4419357-A | 3-(1H-Tetrazol-5-yl)-4(3H)-quinazolinones | THE DOW CHEMICAL COMPANY (US) | 1983-12-06 | — | — | US | disclosed |
| EP-0086340-A1 | 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinones | THE DOW CHEMICAL COMPANY (US) | 1983-08-24 | — | — | EP | disclosed |