Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9501879 | 0.80 | NPC1 (0.56) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11428444 | 0.77 | NPC1 (0.48) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL10937760 | 0.77 | KIT (0.45) | NPC1RAB9AALDH1A1MAPTHTT | |
| SCHEMBL10878740 | 0.74 | JAK1 (0.40) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL11435882 | 0.74 | PARP1 (0.51) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL10935762 | 0.74 | CBLB (0.38) | NPC1RAB9AALDH1A1TP53MAPT | |
| SCHEMBL11430775 | 0.73 | HSP90AA1 (0.41) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11430231 | 0.72 | LMNA (0.56) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11431754 | 0.72 | MAPT (0.40) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11436996 | 0.72 | KDR (0.46) | NPC1RAB9ACASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4186201-A | ANTIALLERGIC AGENTS | RIKER LABORATORIES, INC. (US) | 1980-01-29 | — | — | US | disclosed |
| US-4147694-A | ANTIALLERGENS, ANTIHISTAMINES | RIKER LABORATORIES, INC. (US) | 1979-04-03 | — | — | US | disclosed |