Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | RXRB | P28702 | 2/20 | 0.46 |
| ▸ | RXRG | P48443 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2888586 | 0.88 | MAPT (0.49) | MAPTHPGDALDH1A1KDM4EFFAR4 | |
| SCHEMBL10880568 | 0.86 | MAOA (0.58) | MAPTHPGDALDH1A1KDM4ELMNA | |
| SCHEMBL10879509 | 0.84 | FAAH (0.46) | MAPTHPGDALDH1A1KDM4ELMNA | |
| SCHEMBL24983869 | 0.83 | LMNA (0.56) | HPGDKDM4ELMNAFFAR4SMN1; SMN2 | |
| SCHEMBL10947765 | 0.83 | ALDH1A1 (0.46) | MAPTHPGDALDH1A1KDM4ELMNA | |
| SCHEMBL10879814 | 0.83 | ALDH1A1 (0.46) | MAPTHPGDALDH1A1KDM4ELMNA | |
| SCHEMBL23731587 | 0.81 | HPGD (0.55) | MAPTHPGDALDH1A1KDM4ELMNA | |
| SCHEMBL11563262 | 0.80 | MAOB (0.56) | HPGDALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL384872 | 0.80 | MAOB (0.56) | MAPTHPGDKDM4ELMNAFFAR4 | |
| SCHEMBL21327288 | 0.80 | LMNA (0.52) | MAPTHPGDLMNAFFAR4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109815-B1 | IMPROVEMENTS IN AND RELATING TO SUBSTITUTED TETRAHYDRONA PHTHALENES | ELI LILLY AND COMPANY (US) | 1986-05-28 | — | — | EP | disclosed |
| US-4500545-A | HYPOTENSIVE, ANTISECRETORY AGENTS, AND DOPAMINE ANTAGONIST | ELI LILLY AND COMPANY (US) | 1985-02-19 | — | — | US | disclosed |
| EP-0109815-A1 | Improvements in and relating to substituted tetrahydrona phthalenes | ELI LILLY AND COMPANY (US) | 1984-05-30 | — | — | EP | disclosed |
| US-4448990-A | Hydroxyaminotetralincarboxamides | ELI LILLY AND COMPANY (US) | 1984-05-15 | — | — | US | disclosed |