SCHEMBL10880447

SCHEMBL10880447

OCc1c(F)c(F)c(F)c(-c2ccccc2)c1F

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GCGR P47871 3/20 0.39
PRKAA2 P54646 1/20 0.37
TSHR P16473 1/20 0.34
NOTUM Q6P988 1/20 0.34
DHODH Q02127 2/20 0.34
DHFR P00374 3/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
HTT P42858 1/20 0.33
PDCD1 Q15116 1/20 0.32
CD274 Q9NZQ7 1/20 0.32
BACE1 P56817 1/20 0.32
AR P10275 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10344156 0.90 GCGR (0.40) GCGRPRKAA2TSHRNOTUMMEN1
SCHEMBL247368 0.80 LMNA (0.48) DHODHDHFRLMNAMAPTHTT
SCHEMBL7704707 0.78 LMNA (0.46) DHODHDHFRLMNAMAPTHTT
SCHEMBL7711087 0.78 ALDH1A1 (0.50) NOTUMDHODHDHFRLMNAMAPT
SCHEMBL10920184 0.77 GCGR (0.37) GCGRPRKAA2TSHRNOTUMDHODH
Boric Acid SCHEMBL23928392 0.76 MGLL (0.41) DHODHDHFRLMNAMAPTHTT
SCHEMBL24834542 0.76 POLB (0.30)
Boric Acid SCHEMBL6065759 0.76 MGLL (0.41) DHODHDHFRLMNAMAPTHTT
SCHEMBL12679970 0.75 GCGR (0.52) GCGRTSHRNOTUMLMNAMAPT
SCHEMBL31305580 0.75 LMNA (0.43) DHODHDHFRLMNAMAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012150208-A1 USE OF SUBSTITUTED BENZYL ALCOHOL ESTERS OF CYCLOPROPANECARBOXYLIC ACID FOR CONTROLLING INSECTICIDE-RESISTANT INSECTS BAYER CROPSCIENCE AG (DE) 2012-11-08 WO disclosed
EP-0118873-B1 ACARICIDAL DIFLUOROETHENYLCYCLOPROPANECARBOXYLATES FMC Corporation (US) 1986-06-18 EP disclosed
EP-0049977-B1 INSECTICIDAL (1,1'-BIPHENYL)-3-YLMETHYL ESTERS, THEIR PRODUCTION AND USE AND COMPOSITIONS CONTAINING THEM FMC Corporation (US) 1986-02-26 EP disclosed
US-4552892-A Acaricidal difluoroethenylcyclopropanecarboxylates FMC CORPORATION (US) 1985-11-12 US disclosed
US-4536591-A Insecticidal [1,1'-biphenyl]-3-ylmethyl esters FMC CORPORATION (US) 1985-08-20 US disclosed
EP-0125248-A1 INSECTICIDAL SUBSTITUTED-BIPHENYLMETHYL OXIME ETHERS FMC Corporation (US) 1984-11-21 EP disclosed
EP-0118873-A1 Acaricidal difluoroethenylcyclopropanecarboxylates FMC Corporation (US) 1984-09-19 EP disclosed
WO-1984001772-A1 INSECTICIDAL SUBSTITUTED-BIPHENYLMETHYL OXIME ETHERS FMC CORP (US) 1984-05-10 WO disclosed
US-4434182-A Insecticidal substituted-biphenylmethyl oxime ethers FMC CORPORATION (US) 1984-02-28 US disclosed
US-4402973-A Insecticidal (1,1'-biphenyl)-3-ylmethyl esters FMC CORPORATION (US) 1983-09-06 US disclosed
US-4329518-A INSECTICIDES, ACARICIDES, MITICIDES FMC CORPORATION (US) 1982-05-11 US disclosed
EP-0049977-A1 Insecticidal (1,1'-biphenyl)-3-ylmethyl esters, their production and use and compositions containing them FMC Corporation (US) 1982-04-21 EP disclosed