Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10883500 | 0.88 | TP53 (0.47) | ADRA2CMAPTADRA2BNPC1RAB9A | |
| SCHEMBL10885147 | 0.82 | L3MBTL1 (0.39) | ADRA2CMAPTNPC1RAB9APOLB | |
| SCHEMBL631554 | 0.76 | MAOA (0.55) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL31531622 | 0.76 | CYP3A4 (0.40) | ADRA2CALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL10881731 | 0.75 | MEN1 (0.41) | ADRA2CMAPTADRA2BRAB9AALDH1A1 | |
| SCHEMBL2397579 | 0.75 | GAA (0.60) | ADRA2CMAPTHTTADRA2BNPC1 | |
| Hydrochloric Acid SCHEMBL631888 | 0.75 | MAOA (0.53) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL10886910 | 0.74 | TAAR1 (0.38) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10887323 | 0.74 | ADRA2C (0.51) | ADRA2CMAPTHTTADRA2BNPC1 | |
| SCHEMBL9481271 | 0.73 | MEN1 (0.31) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0081324-B1 | SUBSTITUTED PHARMACOLOGICALLY ACITVE IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos Group Ltd. (FI) | 1986-08-06 | — | — | EP | disclosed |
| US-4517198-A | Diuretic imidazole derivatives | FARMOS GROUP LTD. (FI) | 1985-05-14 | — | — | US | disclosed |
| EP-0081324-A2 | Substituted pharmacologically acitve imidazole derivatives and their preparation and use | Farmos Group Ltd. (FI) | 1983-06-15 | — | — | EP | disclosed |