Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10883145 | 0.84 | TAAR1 (0.31) | HTR1AADRA1DADRA1AADRA1BTAAR1 | |
| SCHEMBL10883500 | 0.83 | TP53 (0.47) | L3MBTL1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL10885162 | 0.82 | ADRA2C (0.51) | L3MBTL1ADRA1AADRA2CCYP3A4CYP2C9 | |
| SCHEMBL10883596 | 0.81 | KCNH2 (0.39) | HTR1ATAAR1 | |
| SCHEMBL10884796 | 0.80 | ADRA2A (0.37) | HTR1AADRA1DADRA1AADRA1BADRA2C | |
| SCHEMBL10886910 | 0.79 | TAAR1 (0.38) | HTR1AADRA1DADRA1AADRA1BTAAR1 | |
| SCHEMBL2103783 | 0.74 | TAAR1 (0.46) | HTR1AADRA1DADRA1AADRA1BTAAR1 | |
| SCHEMBL631554 | 0.74 | MAOA (0.55) | TAAR1NPC1MAPTRAB9A | |
| SCHEMBL10882048 | 0.73 | L3MBTL1 (0.39) | L3MBTL1HTR1AADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL631888 | 0.72 | MAOA (0.53) | TAAR1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0081324-B1 | SUBSTITUTED PHARMACOLOGICALLY ACITVE IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos Group Ltd. (FI) | 1986-08-06 | — | — | EP | claimed |
| US-4517198-A | Diuretic imidazole derivatives | FARMOS GROUP LTD. (FI) | 1985-05-14 | — | — | US | claimed |
| EP-0081324-A2 | Substituted pharmacologically acitve imidazole derivatives and their preparation and use | Farmos Group Ltd. (FI) | 1983-06-15 | — | — | EP | claimed |
| EP-0081324-B1 | SUBSTITUTED PHARMACOLOGICALLY ACITVE IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos Group Ltd. (FI) | 1986-08-06 | — | — | EP | disclosed |
| US-4517198-A | Diuretic imidazole derivatives | FARMOS GROUP LTD. (FI) | 1985-05-14 | — | — | US | disclosed |
| EP-0081324-A2 | Substituted pharmacologically acitve imidazole derivatives and their preparation and use | Farmos Group Ltd. (FI) | 1983-06-15 | — | — | EP | disclosed |