Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7911130 | 0.82 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7125526 | 0.76 | KIF11 (0.45) | LMNASMN1; SMN2GAAHTTRAB9A | |
| SCHEMBL10896574 | 0.76 | CYP2C9 (0.66) | SMN1; SMN2GAAMAPTKCNA5ALDH1A1 | |
| SCHEMBL22932513 | 0.71 | ACHE (0.50) | LMNARAB9AALDH1A1CYP3A4 | |
| SCHEMBL10368035 | 0.71 | HTT (0.56) | LMNASMN1; SMN2HTTKCNA5KMT2A | |
| SCHEMBL1501195 | 0.71 | LMNA (0.58) | LMNASMN1; SMN2GAAHTTMAPT | |
| SCHEMBL8309309 | 0.71 | ABCB1 (0.66) | ALDH1A1ABCB1 | |
| SCHEMBL10069982 | 0.70 | LMNA (0.65) | LMNASMN1; SMN2GAAHTTALDH1A1 | |
| SCHEMBL791922 | 0.70 | MAOB (0.72) | SMN1; SMN2HTTRAB9AABCB1MEN1 | |
| SCHEMBL9837849 | 0.70 | LMNA (0.55) | LMNASMN1; SMN2HTTRAB9AKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4632925-A | INSULIN LOWERING ACTIVITY | HOFFMANN-LA ROCHE INC. (US) | 1986-12-30 | — | — | US | disclosed |