Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10896910 | 0.93 | DRD2 (0.61) | DRD2HTR2AMCHR1 | |
| SCHEMBL10895899 | 0.89 | P2RX7 (0.57) | P2RX7DRD2HTR2AHTR1A | |
| SCHEMBL10892073 | 0.84 | HTR7 (0.55) | P2RX7HTR1A | |
| SCHEMBL11163898 | 0.84 | USP2 (0.61) | P2RX7DRD2HTR2AHTR1A | |
| Bromide SCHEMBL11240851 | 0.83 | HTR7 (0.54) | P2RX7HTR1A | |
| Bromide SCHEMBL10898200 | 0.83 | USP2 (0.60) | P2RX7DRD2HTR2AHTR1A | |
| SCHEMBL11244560 | 0.83 | HTR1A (0.55) | DRD2HTR2AHTR1A | |
| SCHEMBL10896546 | 0.83 | P2RX7 (0.53) | P2RX7DRD2HTR2AHTR1A | |
| Bromide SCHEMBL10894851 | 0.82 | HTR1A (0.54) | DRD2HTR2AHTR1A | |
| SCHEMBL10896209 | 0.82 | HTR1A (0.54) | P2RX7HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4352811-A | NEUROLEPTIC AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1982-10-05 | — | — | US | claimed |
| EP-0079564-B1 | 3-(1-SUBSTITUTED-4-PIPERIDYL)-1,2-BENZISOXAZOLES, A PROCESS FOR THE PREPARATION THEREOF, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-03-19 | — | — | EP | disclosed |
| EP-0079564-A1 | 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles, a process for the preparation thereof, a pharmaceutical composition comprising the same, and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-05-25 | — | — | EP | disclosed |
| US-4352811-A | NEUROLEPTIC AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1982-10-05 | — | — | US | disclosed |