Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 8/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10899375 | 0.87 | KMT2A (0.43) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL10899410 | 0.81 | NPC1 (0.40) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL10902026 | 0.80 | MKNK2 (0.43) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL10899791 | 0.80 | MAPK14 (0.45) | ALDH1A1GAAMAPK13MAPK12MAPK11 | |
| SCHEMBL10902490 | 0.80 | KMT2A (0.43) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL10901637 | 0.80 | PDGFRB (0.48) | NPC1RAB9AKDM4EMAPK13MAPK12 | |
| Iodide SCHEMBL10902989 | 0.78 | ACHE (0.36) | NPC1RAB9AKMT2AMEN1CYP1A2 | |
| SCHEMBL10902115 | 0.76 | RAB9A (0.46) | NPC1RAB9AKMT2AMEN1LMNA | |
| SCHEMBL10901779 | 0.76 | KIF11 (0.49) | NPC1RAB9AALDH1A1MAPTMAPK13 | |
| SCHEMBL10906164 | 0.75 | NPC1 (0.40) | NPC1RAB9AKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4600719-A | Tetrahydropyridine and piperidine derivatives | CIBA GEIGY CORPORATION (US) | 1986-07-15 | — | — | US | disclosed |
| US-4210655-A | Anti-depressant benzofuranyl piperidines | CIBA-GEIGY CORPORATION (US) | 1980-07-01 | — | — | US | disclosed |