Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MB | P02144 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31180315 | 0.81 | CYP11B1 (0.31) | CYP11B1CYP11B2AHRPDE3BPDE3A | |
| SCHEMBL428384 | 0.71 | CYP11B1 (0.51) | CYP3A4HPGDCRHBPCRHR2HSD17B10 | |
| SCHEMBL10916352 | 0.71 | CYP11B1 (0.40) | HPGDHSD17B10CYP11B1CYP11B2AHR | |
| SCHEMBL10916724 | 0.70 | CYP11B1 (0.51) | CYP11B1CYP11B2AHRPDE3BPDE3A | |
| SCHEMBL20714433 | 0.68 | PDE7A (0.39) | CYP3A4AHRPDE3BPDE3AMB | |
| SCHEMBL10917370 | 0.67 | PGR (0.42) | CYP3A4HPGDCRHBPCRHR2HSD17B10 | |
| SCHEMBL14805480 | 0.67 | ALDH1A1 (0.39) | CYP3A4HPGDHSD17B10CYP11B1CYP11B2 | |
| SCHEMBL30646022 | 0.67 | CYP11B1 (0.41) | CYP3A4CYP11B1CYP11B2PDE3BPDE3A | |
| SCHEMBL293956 | 0.67 | CYP11B1 (0.41) | CYP3A4CYP11B1CYP11B2PDE3BPDE3A | |
| SCHEMBL19805147 | 0.64 | ABCC9 (0.31) | CYP11B1CYP11B2PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0093922-B1 | BENZOXAZIN-2-ONES, THEIR PREPARATION AND THERAPEUTIC AGENTS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1986-12-30 | — | — | EP | disclosed |
| US-4518597-A | THROMBOSIS, ARTERIOSCLEROSIS, ANTITUMOR, ANTICOAGULANTS | DR. KARL THOMAE GMBH (DE) | 1985-05-21 | — | — | US | disclosed |
| EP-0093922-A2 | Benzoxazin-2-ones, their preparation and therapeutic agents containing these compounds | Dr. Karl Thomae GmbH (DE) | 1983-11-16 | — | — | EP | disclosed |