Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10918602 | 0.86 | TSHR (0.55) | DRD2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL10922313 | 0.83 | MEN1 (0.51) | KMT2AMEN1MAPTALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL10921886 | 0.82 | KMT2A (0.58) | DRD2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL10918979 | 0.81 | ALDH1A1 (0.52) | KMT2AMEN1MAPTALDH1A1HSD17B10 | |
| SCHEMBL10917978 | 0.81 | ALDH1A1 (0.49) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL10919669 | 0.80 | NPC1 (0.50) | KMT2AMEN1MAPTALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL10922643 | 0.80 | POLB (0.42) | DRD2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL10916248 | 0.80 | ALDH1A1 (0.51) | KMT2AMEN1MAPTALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL10917805 | 0.79 | NPC1 (0.49) | KMT2AMEN1MAPTALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL10919861 | 0.79 | MAPT (0.58) | DRD2KMT2AMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064704-B1 | 4-AMINOMETHYL-5-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-04-16 | — | — | EP | disclosed |
| US-4381393-A | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-04-26 | — | — | US | disclosed |
| EP-0064704-A1 | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |