Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10921886 | 0.89 | KMT2A (0.58) | MEN1KMT2AL3MBTL1LMNAMAPT | |
| SCHEMBL10918399 | 0.84 | CCR2 (0.45) | KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL10918979 | 0.84 | ALDH1A1 (0.52) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL10917978 | 0.84 | ALDH1A1 (0.49) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL10920934 | 0.83 | TSHR (0.51) | KMT2AL3MBTL1LMNAMAPTALDH1A1 | |
| SCHEMBL10924276 | 0.83 | LMNA (0.51) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL10922643 | 0.83 | POLB (0.42) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL10916248 | 0.83 | ALDH1A1 (0.51) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL10918184 | 0.83 | DRD2 (0.44) | MEN1KMT2AL3MBTL1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL10919861 | 0.82 | MAPT (0.58) | KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064704-B1 | 4-AMINOMETHYL-5-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-04-16 | — | — | EP | disclosed |
| US-4381393-A | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-04-26 | — | — | US | disclosed |
| EP-0064704-A1 | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |